TCA's

TCA’s work by increasing the levels of serotonin and noradrenaline in the brain by slowing down the rate of their reabsorption by certain nerve cells.  You may see an improvement within 2 weeks however full benefits of the drug may not be noticed for 2-4 weeks.  TCA’s are known to have more side effects than the newer class of antidepressant of SSRIs as they are not as selective in which nerve cells they target.  They are usually prescribed after as SSRI has been trialled and considered unsuitable.

To read about others personal experiences with these antidepressants visit the Medications section of the depressioNet forums.  These accounts are personal and all experiences are different and should not be replaced by the advice of your Healthcare Professional.  

For access to pharamceutical information regarding the above medictions visit the PBS Website by clicking below

Side Effects

 You may experience the following side effects when taking TCA antidepressants;

• Constipation
• Difficulty Urinating
• Blurred Vision
• Dry Mouth 
• Weight Gain
• Sexual Dysfunction
• Drowsiness
• Low Blood Pressure
• Increased Appetite
• Weakness

These side effects should settle after 2 weeks

Warnings

If you have the following conditions alert you Healthcare Professional before beginning a course of TCA Antidepressant;

• Narrow Angle Glaucoma
• Enlarged Prostate
• Heart Disease (higher rate of heart attack)
• May affect blood sugar levels
• Diabetes
• History of seizures or thyroid problems

Withdrawal Symptoms

You may experience the following effects when coming off a TCA antidepressant;

• Nausea
• Headache
• Dizziness
• Flu like Symptoms

Suicidal Feelings

Antidepressants have been linked to worsening suicidal emotions.  This is likely to occur at the beginning of a new treatment or as dosage is increased, however they can occur at any time during treatment.  It is important to monitor suicidal tendencies when beginning new treatment and to inform your Healthcare Professional.