MAOI's

MAOI's
(Monoamine Oxidase Inhibitor)

MAOI’s prevent the enzyme monoamine oxidase from metabolizing the neurotransmitters norepinephrine, serotonin and dopamine in the brain so that they are contained for longer in the brain.  The side effects caused by MAOI’s can be serious so these anti depressants are usually prescribed when SSRI’s have not improved the condition or are considered unsuitable.

To read about others personal experiences with these antidepressants visit the Medications section of the depressioNet forums.  These accounts are personal and all experiences are different and should not be replaced by the advice of your Healthcare Professional.
 

For access to pharamceutical information regarding the above medictions visit the PBS Website by clicking below

Side Effects

You may experience the following side effects when taking MAOI antidepressants;

• Drowsiness
• Nausea
• Diarrhea
• Stomach Upset
• Fatigue
• Dry Mouth
• Dizziness
• Low Blood Pressure
• Light-headedness
• Decreased Sexual Function
• Decreased Urine Output
• Sleep Disturbances
• Muscle Twitching
• Weight Gain
• Blurred Vision
• Headache
• Increased Appetite
• Restlessness
• Shakiness
• Trembling
• Weakness
• Increased Sweating

Warnings

MAOIs may have dangerous affects when combined with certain food and beverages such as;

• Foods containing tyamine
• Cheeses
• Pickled Foods
• Chocolates
• Certain Meats
• Beer
• Wine (which can increase Blood Pressure and risk of stroke)
• Avoidance of other anti depressants
• Avoidance of over the counter decongestants
• St. John’s Wort
• Over the counter weight loss products

Serotonin Syndrome

Serotonin Syndrome is a rare yet fatal illness which occurs when levels of serotonin in the brain are excessively high.  This can be a result of an interaction between SSRI's and MAOI's or St John’s Wort.  These antidepressants cannot be taken within 2 weeks of each other.  Inform your doctor if you are taking or have taken an MAOI.

Suicidal Feelings

Antidepressants have been linked to worsening suicidal emotions.  This is likely to occur at the beginning of a new treatment or as dosage is increased, however they can occur at any time during treatment.  It is important to monitor suicidal tendencies when beginning new treatment and to inform your Healthcare Professional.